Your response should include the historical context of botulinum toxin which may include; 1) History of Bacterium Clostridium Botulinum 2) The discovery of BoNTA for therapeutic use 3) The discovery of BoNTA for aesthetic purposes. Your response should also include the historical context of dermal fillers which may include; 1) The historical use of the dermal fillers first used for therapeutic indications 2) The use of dermal fillers agents for HIV-associated facial lipoatrophy 3) The historical context and development of permanent and biodegredable dermal filler agents
